PhD Position in Immunology and Neuroscience (f/m/d)

Medizin 3

25.025 Stunden

auf 36 Monate befristet

ab 01.09.2025

Eingruppierung gemäß TV-L

          
            Universitätsklinikum Erlangen
 Medizinische Klinik 3 - Rheumatologie und Immunologie
Prof. Dr. Mario Zaiss
 Glückstr. 4a
 91054 Erlangen
          
        

Ansprechperson bei Fragen
Prof. Dr. Mario Zaiss
Professor für Immuntoleranz und Autoimmunität
Telefon: 09131 85-43212

PhD Position in Immunology and Neuroscience (f/m/d)

Job-Nr.: 10270

Prof. Dr. Mario Zaiss
Professor für Immuntoleranz und Autoimmunität
Telefon: 09131 85-43212

                Universitätsklinikum Erlangen
 Medizinische Klinik 3 - Rheumatologie und Immunologie
Prof. Dr. Mario Zaiss
 Glückstr. 4a
 91054 Erlangen
              

PhD Position in Immunology and Neuroscience (f/m/d)
Job-Nr.: 10270

Universitätsklinikum Erlangen
 Medizinische Klinik 3 - Rheumatologie und Immunologie
Prof. Dr. Mario Zaiss
 Glückstr. 4a
 91054 Erlangen

Ansprechperson bei Fragen
Prof. Dr. Mario Zaiss
Professor für Immuntoleranz und Autoimmunität
Telefon: 09131 85-43212

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The research group of Prof. Mario Zaiss (www.zaisslab.com ) at the Medical Department 3 is offering a fully funded PhD position (TVL E13 65%) for 3 years to investigate the gut-CNS-joint axis in rheumatoid arthritis (RA). Chronic inflammatory diseases, such as RA, are known to activate the central nervous system (CNS), yet little is understood about how environmental factors enable the CNS to suppress peripheral inflammation. Our research has identified gut microbiota-derived histamin as a key factor in this process. We have demonstrated that low levels of this metabolite activate the enteric nervous system, increase inhibitory neurotransmitter concentrations in the spinal cord, and restore homeostatic microglia, ultimately reducing joint inflammation (doi.org/10.1101/2024.07.11.603031).

Graphical abstract

Building on these findings, this PhD project will explore how gut-derived metabolites, modulate neuroimmune interactions to drive the resolution of arthritis.

Tasks:

The research will employ state-of-the-art analytical techniques and provide opportunities for translational studies from preclinical models to patient applications.
The doctoral candidate (f/m/d) will conduct experimental research on the gut-CNS-joint axis in RA, investigating the role of histamine signaling and microbiota-derived metabolites in immune regulation.
The project will involve the use of advanced methods in molecular biology, imaging, and neuroimmunology assays, with a strong emphasis on translational research.
The candidate (f/m/d) will work in an interdisciplinary setting, collaborating with experts in immunology, neuroscience, and microbiome research, while being expected to publish findings in peer-reviewed journals and present at international conferences

Comments:

The position offers a stimulating research environment with access to cutting-edge facilities and collaboration with leading experts in the field. Opportunities for professional development, international conferences, and career advancement are available.
The start is possible immediately, preferably from 01.09.2025.
To apply, candidates (f/m/d) should submit a single PDF document including a cover letter outlining research interests and motivation, a CV detailing academic background and relevant experience, transcripts and degree certificates, and contact details of two academic referees.

Know-How:

Applicants (f/m/d) should have a Master’s degree (or equivalent) in Immunology, Neuroscience, Microbiology, Molecular Biology, or a related field, with a strong background in neuroimmunology, microbiome research, or inflammation
Experience with cell culture, animal models, molecular biology, and/or imaging techniques is highly desirable.
The ideal candidate (f/m/d) will be motivated, independent, and capable of working collaboratively, with strong written and verbal communication skills in English.