PhD Student for super-resolution microscopy-based investigations of the glycocalyx (m/f/d)

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The Möckl research group is located at the University Clinic/CITABLE and the Max Planck Institute for the Science of Light. Our research relies on a highly transdisciplinary approach, utilizing light to investigate and manipulate biological systems. We employ cutting-edge super-resolution methods such as DNA-PAINT, dSTORM, and iSCAT microscopy to unravel spatiotemporal dynamics of biomolecules at the nanometer and microsecond scales, complement our microscopy studies with biophysical investigations of cell mechanics, and develop photoactivatable therapeutic compounds for new strategies in light-based therapy.

Every cell in the human body is surrounded by the glycocalyx, a complex layer consisting of glycans (carbohydrates or sugar chains), either free or attached to proteins and lipids. Over the past years, research by other groups and the Möckl group has brought the glycocalyx into the spotlight of biological and biomedical research, showing its relevance in a range of vital cellular processes. These initial insights motivate a concerted effort to unravel the functional role of the glycocalyx in health and disease.

The Möckl Lab is part of the recently launched EU-wide consortium “GLYCOCALYX” (funded by the ERC), which investigates the self-organization and barrier function of the mammalian glycocalyx (see here for the consortium and all members: https://www.glycocalyx.org/).